Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo.

Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, et al.
(2023) Molecular Therapy - Methods and Clinical Development, 29 p.381-394
Journal article

A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates

Danish M. Anwer, Francesco Gubinelli, Yunus A. Kurt, Livija Sarauskyte, Febe Jacobs, et al.
(2023) PLoS ONE, 18
Journal article

Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia

Isaac Canals, Andrea Comella-Bolla, Efrain Cepeda-Prado, Natalia Avaliani, James A Crowe, et al.
(2023) Brain Communications, 5 p.1-16
Journal article

Automated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology

Luis Quintino, Francesco Gubinelli, Livija Sarauskyte, Elin Arvidsson, Marcus Davidsson, et al.
(2022) Journal of Neuroscience Methods, 378
Journal article

Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests

F. Gubinelli, G. Cazzolla, M. Negrini, I. Kulacz, A. Mehrdadian, et al.
(2022) Behavioural Brain Research, 429
Journal article

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Patrick Aldrin-Kirk, Malin Åkerblom, Tiago Cardoso, Sara Nolbrant, Andrew F. Adler, et al.
(2022) Stem Cell Reports, 17 p.159-172
Journal article

Small scale adeno-associated virus-vector production for preclinical gene delivery based on chloroform precipitation

Marcus Davidsson, Andreas Heuer
(2022) Neural Regeneration Research, 17 p.99-100
Journal article review

Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits

Matilde Negrini, Giuseppe Tomasello, Marcus Davidsson, Alexis Fenyi, Cécile Adant, et al.
(2022) Journal of Parkinson's Disease, 12 p.1133-1153
Journal article

Editorial : Regeneration and Brain Repair

Daniella Rylander Ottosson, Sofia Grade, Andreas Heuer
(2021) Frontiers in Cellular Neuroscience, 15
Journal article (comment)

Neurotransmitter Release of Reprogrammed Cells Using Electrochemical Detection Methods

Andreas Heuer
(2021) Methods in Molecular Biology, 2352 p.201-226
Book chapter

Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson’s Disease Model

Sophie V. Precious, Gaynor A. Smith, Andreas Heuer, Ines Jaeger, Emma L. Lane, et al.
(2020) Frontiers in Neuroscience, 14
Journal article

A comparison of AAV-vector production methods for gene therapy and preclinical assessment

Marcus Davidsson, Matilde Negrini, Swantje Hauser, Alexander Svanbergsson, Marcus Lockowandt, et al.
(2020) Scientific Reports, 10
Journal article

AAV Production Everywhere : A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction

Matilde Negrini, Gang Wang, Andreas Heuer, Tomas Björklund, Marcus Davidsson
(2020) Current Protocols in Neuroscience, 93 p.103-103
Journal article

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, et al.
(2020) Nature Communications, 11
Journal article

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

Margarita Chumarina, Kaspar Russ, Carla Azevedo, Andreas Heuer, Maria Pihl, et al.
(2019) Acta Neuropathologica Communications, 7
Journal article

Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy

Elena Espa, Erik K.H. Clemensson, Kelvin C. Luk, Andreas Heuer, Tomas Björklund, et al.
(2019) Movement Disorders, 34 p.1699-1710
Journal article

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

Marcus Davidsson, Paula Díaz-Fernández, Marcos Torroba, Oliver D. Schwich, Patrick Aldrin-Kirk, et al.
(2018) RNA, 24 p.673-687
Journal article

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

Patrick Aldrin-Kirk, Andreas Heuer, Daniella Ottosson, Marcus Davidsson, Bengt Mattsson, et al.
(2018) Neurobiology of Disease, 109 p.148-162
Journal article

In vivo electrochemical studies of optogenetic control of glutamate signaling measured using enzyme-based ceramic microelectrode arrays

Jason J. Burmeister, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Yi Ai, et al.
(2018) Neuromethods, 130 p.327-351
Book chapter

Automated Operant Assessments of Huntington's Disease Mouse Models

Emma Yhnell, Andreas Heuer
(2018) Methods in molecular biology (Clifton, N.J.), 1780 p.143-162
Journal article

Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus

Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia, et al.
(2017) Stem Cells International, 2017
Journal article

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

Sara Nolbrant, Andreas Heuer, Malin Parmar, Agnete Kirkeby
(2017) Nature Protocols, 12 p.1962-1979
Journal article

Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease

Agnete Kirkeby, Sara Nolbrant, Katarina Tiklova, Andreas Heuer, Nigel Kee, et al.
(2017) Cell Stem Cell, 20 p.135-148
Journal article

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, et al.
(2017) Stem Cell Reports, 9 p.1207-1220
Journal article

HESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation

Andreas Heuer, Agnete Kirkeby, Ulrich Pfisterer, Marie E. Jönsson, Malin Parmar
(2016) Experimental Neurology, 282 p.78-85
Journal article

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

Patrick Aldrin-Kirk, Andreas Heuer, Gang Wang, Bengt Mattsson, Martin Lundblad, et al.
(2016) Neuron, 90 p.955-968
Journal article

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons.

Shane Grealish, Andreas Heuer, Tiago Cardoso, Agnete Kirkeby, Marie Jönsson, et al.
(2015) Stem Cell Reports, 4 p.975-983
Journal article

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease.

Shane Grealish, Elsa Diguet, Agnete Kirkeby, Bengt Mattsson, Andreas Heuer, et al.
(2014) Cell Stem Cell, 15 p.653-665
Journal article