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MalinÅ

Malin Åkerblom

Project manager

MalinÅ

microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Author

  • Malin Åkerblom
  • Rebecca Petri
  • Rohit Sachdeva
  • Thies Klüssendorf
  • Bengt Mattsson
  • Bernhard Gentner
  • Johan Jakobsson

Summary, in English

New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.

Department/s

  • Molecular Neurogenetics
  • Neurobiology
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2014

Language

English

Pages

1580-1588

Publication/Series

Development: For advances in developmental biology and stem cells

Volume

141

Issue

7

Document type

Journal article

Publisher

The Company of Biologists Ltd

Topic

  • Developmental Biology

Status

Published

Research group

  • Molecular Neurogenetics
  • Neurobiology

ISBN/ISSN/Other

  • ISSN: 1477-9129