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MalinÅ

Malin Åkerblom

Project manager

MalinÅ

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.

Author

  • Malin Åkerblom
  • Rohit Sachdeva
  • Isabelle Barde
  • Sonia Verp
  • Bernhard Gentner
  • Didier Trono
  • Johan Jakobsson

Summary, in English

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.

Department/s

  • Molecular Neurogenetics
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2012

Language

English

Pages

8879-8889

Publication/Series

The Journal of Neuroscience : the official journal of the Society for Neuroscience

Volume

32

Issue

26

Document type

Journal article

Publisher

Society for Neuroscience

Topic

  • Neurosciences

Status

Published

Research group

  • Molecular Neurogenetics

ISBN/ISSN/Other

  • ISSN: 1529-2401