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MalinÅ

Malin Åkerblom

Project manager

MalinÅ

Functional Studies of microRNAs in Neural Stem Cells : Problems and Perspectives

Author

  • Malin Åkerblom
  • Rohit Sachdeva
  • Johan Jakobsson

Summary, in English

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.

Department/s

  • Molecular Neurogenetics
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2012

Language

English

Publication/Series

Frontiers in Neuroscience

Volume

6

Document type

Journal article

Publisher

Frontiers Media S. A.

Topic

  • Neurosciences

Status

Published

Research group

  • Molecular Neurogenetics

ISBN/ISSN/Other

  • ISSN: 1662-4548