
Marcus Davidsson
Postdoctoral fellow

About
I received my Master’s degree in Molecular Biology from Lund University in 2011. Shortly thereafter I joined Molecular Neuromodulation (MNM) to start a PhD under the supervision of Tomas Björklund. During my PhD I worked on developing novel methods for DNA barcoding, and how to apply this technique to study biological functions in the brain.
My main research interests focus on developing novel AAV capsids using DNA barcoding and how to utilize these vectors in clinical as well as preclinical applications.
Research Experience and Education
2019 – Present Postdoctoral fellow, Barrow Neurological Institute/Lund University
2018 – 2019 Postdoctoral fellow, Michigan State University/Lund University
2018 - 2018 Postdoctoral employee Molecular Neuromodulation, Lund University
2012 – 2018 PhD in Neuroscience, Molecular Neuromodulation Lund University
Thesis defended: 23rd of March 2018
Thesis title: Viral vector barcoding - a BRAVE tool for next generation gene therapy
2009 – 2011 M.Sc. in Molecular Biology at Lund University
Honors and Awards
2019 Swedish Society for Medical Research (2 years Postdoc stipend)
2018 Birgit och Hellmuth Hertz Foundation (3 years International Postdoc grant)
2018 Anna Greta Crafoord Prize awarded for the best thesis work at Faculty of Medicine, Lund University
Publications
Displaying of publications. Sorted by year, then title.
Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology
Rana Soylu Kucharz, Natalie Adlesic, Marcus Davidsson, Tomas Björklund, Maria Björkqvist, et al.
(2023)
PreprintAutomated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology
Luis Quintino, Francesco Gubinelli, Livija Sarauskyte, Elin Arvidsson, Marcus Davidsson, et al.
(2022) Journal of Neuroscience Methods, 378
Journal articleLateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests
F. Gubinelli, G. Cazzolla, M. Negrini, I. Kulacz, A. Mehrdadian, et al.
(2022) Behavioural Brain Research, 429
Journal articleA novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants
Patrick Aldrin-Kirk, Malin Åkerblom, Tiago Cardoso, Sara Nolbrant, Andrew F. Adler, et al.
(2022) Stem Cell Reports, 17 p.159-172
Journal articleSmall scale adeno-associated virus-vector production for preclinical gene delivery based on chloroform precipitation
Marcus Davidsson, Andreas Heuer
(2022) Neural Regeneration Research, 17 p.99-100
Journal article reviewSequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits
Matilde Negrini, Giuseppe Tomasello, Marcus Davidsson, Alexis Fenyi, Cécile Adant, et al.
(2022) Journal of Parkinson's Disease, 12 p.1133-1153
Journal articleNext-Generation Gene Therapy for Parkinson's Disease Using Engineered Viral Vectors
Tomas Björklund, Marcus Davidsson
(2021) Journal of Parkinson's Disease, 11 p.209-217
Journal article reviewA comparison of AAV-vector production methods for gene therapy and preclinical assessment
Marcus Davidsson, Matilde Negrini, Swantje Hauser, Alexander Svanbergsson, Marcus Lockowandt, et al.
(2020) Scientific Reports, 10
Journal articleAAV Production Everywhere : A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction
Matilde Negrini, Gang Wang, Andreas Heuer, Tomas Björklund, Marcus Davidsson
(2020) Current Protocols in Neuroscience, 93 p.103-103
Journal articleA systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, et al.
(2019) Proceedings of the National Academy of Sciences of the United States of America, 116 p.27053-27062
Journal articleMolecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing
Marcus Davidsson, Paula Díaz-Fernández, Marcos Torroba, Oliver D. Schwich, Patrick Aldrin-Kirk, et al.
(2018) RNA, 24 p.673-687
Journal articleChemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum
Patrick Aldrin-Kirk, Andreas Heuer, Daniella Ottosson, Marcus Davidsson, Bengt Mattsson, et al.
(2018) Neurobiology of Disease, 109 p.148-162
Journal articleDestabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain
Luis Quintino, Angrit Namislo, Marcus Davidsson, Ludivine S. Breger, Patrick Kavanagh, et al.
(2018) Molecular Therapy - Methods and Clinical Development, 11 p.29-39
Journal articleA novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing
Marcus Davidsson, Paula Diaz-Fernandez, Oliver D. Schwich, Marcos Torroba, Gang Wang, et al.
(2016) Scientific Reports, 6
Journal articleNovel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklund
(2014) PLoS ONE, 9
Journal articleSkeletal muscle atrophy in r6/2 mice - altered circulating skeletal muscle markers and gene expression profile changes.
Anna Magnusson-Lind, Marcus Davidsson, Edina Silajdzic, Christian Hansen, Andy McCourt, et al.
(2014) Journal of Huntington's disease, 3 p.13-24
Journal article