PhD thesis

On April 13, 2018 Patrick Aldrin-Kirk of the MNM team with great success defended his PhD thesis.

Titled "Dissection of basal ganglia circuitry and DA grafts in Parkinson’s disease using viral vectors" this thesis very nicely summarises the efforts in the MNM team to elucidate mechanisms behind multiple forms of dyskinesias in Parkinson's disease and furthers the field of chemogenetics. Thesis opponent was Vania Broccoli, San Raffaele Scientific Institute Milan, Italy. Congratulations Patrick!

Publications

Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain.

Aldrin-Kirk P, Björklund T.

Methods Mol Biol. 2019;1937:59-87. doi: 10.1007/978-1-4939-9065-8_4.

PMID: 30706390

 

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E.

Brain. 2018 Jul 1;141(7):2014-2031. doi: 10.1093/brain/awy126.

PMID: 29788236 

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing.

Davidsson M, Díaz-Fernández P, Torroba M, Schwich OD, Aldrin-Kirk P, Quintino L, Heuer A, Wang G, Lundberg C, Björklund T.

RNA. 2018 May;24(5):673-687. doi: 10.1261/rna.063925.117. Epub 2018 Jan 31.

PMID: 29386333 

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum.

Aldrin-Kirk P, Heuer A, Rylander Ottosson D, Davidsson M, Mattsson B, Björklund T.

Neurobiol Dis. 2018 Jan;109(Pt A):148-162. doi: 10.1016/j.nbd.2017.10.010. Epub 2017 Oct 14.

PMID: 29037828

 

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor.

Aldrin-Kirk P, Heuer A, Wang G, Mattsson B, Lundblad M, Parmar M, Björklund T.

Neuron. 2016 Jun 1;90(5):955-68. doi: 10.1016/j.neuron.2016.04.017. Epub 2016 May 5.

PMID: 27161524 

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang ZY, Roybon L, Melki R, Li JY.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.

PMID: 25296989

 

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

Aldrin-Kirk P, Davidsson M, Holmqvist S, Li JY, Björklund T.

PLoS One. 2014 Jul 7;9(7):e100869. doi: 10.1371/journal.pone.0100869. eCollection 2014.

PMID: 24999658