Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

Martino Avallone, Joaquin Pardo, Tadiwos F. Mergiya, Jana Rajova, Atte Räsänen, et al.
(2023) Frontiers in Molecular Neuroscience, 16
Journal article

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo.

Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, et al.
(2023) Molecular Therapy - Methods and Clinical Development, 29 p.381-394
Journal article

Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology

Rana Soylu Kucharz, Natalie Adlesic, Marcus Davidsson, Tomas Björklund, Maria Björkqvist, et al.
(2023)
Preprint

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Patrick Aldrin-Kirk, Malin Åkerblom, Tiago Cardoso, Sara Nolbrant, Andrew F. Adler, et al.
(2022) Stem Cell Reports, 17 p.159-172
Journal article

In vivo conversion of dopamine neurons in mouse models of Parkinson's disease - a future approach for regenerative therapy?

Malin Parmar, Anders Björklund, Tomas Björklund
(2021) Current Opinion in Genetics & Development, 70 p.76-82
Journal article review

FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation

Alexander Svanbergsson, Fredrik Ek, Isak Martinsson, Jordi Rodo, Di Liu, et al.
(2021) Neurotherapeutics, 18 p.1692-1709
Journal article

Next-Generation Gene Therapy for Parkinson's Disease Using Engineered Viral Vectors

Tomas Björklund, Marcus Davidsson
(2021) Journal of Parkinson's Disease, 11 p.209-217
Journal article review

AAV Production Everywhere : A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction

Matilde Negrini, Gang Wang, Andreas Heuer, Tomas Björklund, Marcus Davidsson
(2020) Current Protocols in Neuroscience, 93 p.103-103
Journal article

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, et al.
(2019) Proceedings of the National Academy of Sciences of the United States of America, 116 p.27053-27062
Journal article

Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy

Elena Espa, Erik K.H. Clemensson, Kelvin C. Luk, Andreas Heuer, Tomas Björklund, et al.
(2019) Movement Disorders, 34 p.1699-1710
Journal article

Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

Carl Rosenblad, Qin Li, Elsa Y Pioli, Sandra Dovero, André S L M Antunes, et al.
(2019) Brain : a journal of neurology , p.2402-2416
Journal article

Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain

Patrick Aldrin-Kirk, Tomas Björklund
(2019) Methods in molecular biology (Clifton, N.J.), 1937 p.59-87
Journal article

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

Julie Tordo, Claire O'Leary, André S.L.M. Antunes, Nuria Palomar, Patrick Aldrin-Kirk, et al.
(2018) Brain, 141 p.2014-2031
Journal article

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

Marcus Davidsson, Paula Díaz-Fernández, Marcos Torroba, Oliver D. Schwich, Patrick Aldrin-Kirk, et al.
(2018) RNA, 24 p.673-687
Journal article

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

Patrick Aldrin-Kirk, Andreas Heuer, Daniella Ottosson, Marcus Davidsson, Bengt Mattsson, et al.
(2018) Neurobiology of Disease, 109 p.148-162
Journal article

Repairing the brain : Gene therapy

Tomas Björklund
(2018) Journal of Parkinson's Disease, 8 p.123-130
Journal article review

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

Marcus Davidsson, Paula Diaz-Fernandez, Oliver D. Schwich, Marcos Torroba, Gang Wang, et al.
(2016) Scientific Reports, 6
Journal article

Identification of multiple QTLs linked to neuropathology in the engrailed-1 heterozygous mouse model of Parkinson's disease

Zuzanna Kurowska, Michael Jewett, Per Ludvik Brattås, Itzia Jimenez, Xuyian Kenéz, et al.
(2016) Scientific Reports, 6
Journal article

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

Patrick Aldrin-Kirk, Andreas Heuer, Gang Wang, Bengt Mattsson, Martin Lundblad, et al.
(2016) Neuron, 90 p.955-968
Journal article

Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

Tomas Björklund
(2016) Methods in Molecular Biology, 1382 p.41-56
Journal article

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level

Trine A. Kristiansen, Elin Jaensson Gyllenbäck, Alya Zriwil, Tomas Björklund, Jeremy A. Daniel, et al.
(2016) Immunity, 45 p.346-357
Journal article

Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.

Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklund
(2014) PLoS ONE, 9
Journal article

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Staffan Holmqvist, Oldriska Chutna, Luc Bousset, Patrick Aldrin-Kirk, Wen Li, et al.
(2014) Acta Neuropathologica, 128 p.805-820
Journal article

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

Erik Cederfjäll, Nathalie Nilsson, Gurdal Sahin, Yaping Chu, Elisabeth Nikitidou, et al.
(2013) Scientific Reports, 3
Journal article

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

Christian Hansen, Tomas Björklund, Géraldine Petit, Martin Lundblad, Reena Murmu, et al.
(2013) Neurobiology of Disease, 56C p.145-155
Journal article

Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons

Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kirik
(2012) Neurobiology of Disease, 47 p.367-377
Journal article

Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.

Erik Cederfjäll, Gurdal Sahin, Deniz Kirik, Tomas Björklund
(2012) Molecular Therapy, 20 p.1315-1326
Journal article

Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.

Sofia Hult Lundh, Rana Soylu, Tomas Björklund, Bengt F Belgardt, Jan Mauer, et al.
(2011) Cell Metabolism, 13 p.428-439
Journal article

Gene therapy for Parkinson's disease shows promise.

Anders Björklund, Tomas Björklund
(2011) Science Translational Medicine, 3 p.1-79
Journal article

Gene therapy for Parkinson's disease.

Tomas Björklund, Jeffrey H Kordower
(2010) Movement Disorders, 25 Suppl 1 p.161-173
Journal article

Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.

Tomas Björklund, Thomas Carlsson, Erik Cederfjäll, Manolo Carta, Deniz Kirik
(2010) Brain, 133 p.496-511
Journal article

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

Mari Iwamoto, Tomas Björklund, Cecilia Lundberg, Deniz Kirik, Thomas J. Wandless
(2010) Chemistry and Biology, 17 p.981-988
Journal article

Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

Hemraj B. Dodiya, Tomas Björklund, James, III Stansell, Ronald J. Mandel, Deniz Kirik, et al.
(2010) Molecular Therapy, 18 p.579-587
Journal article

Gene therapy for dopamine replacement.

Tomas Björklund, Erik Cederfjäll, Deniz Kirik
(2010) Progress in Brain Research, 184 p.221-235
Journal article review

Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

Tomas Björklund, Helene Hall, Nathalie Breysse, Charlotte Soneson, Thomas Carlsson, et al.
(2009) Journal of Neurochemistry, 111 p.355-367
Journal article

Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

Ludovic Leriche, Tomas Björklund, Nathalie Breysse, Laurent Besret, Marie-Claude Gregoire, et al.
(2009) Journal of Neuroscience, 29 p.1544-1553
Journal article

Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

Tomas Björklund
(2009) Lund University Faculty of Medicine Doctoral Dissertation Series, 2009:117
Dissertation

Gene therapy for dopamine replacement in Parkinson's disease.

Anders Björklund, Tomas Björklund, Deniz Kirik
(2009) Science Translational Medicine, 1 p.2-2
Journal article

Scientific rationale for the development of gene therapy strategies for Parkinson's disease.

Tomas Björklund, Deniz Kirik
(2009) Biochimica et Biophysica Acta - Molecular Basis of Disease, 1792 p.703-713
Journal article

Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.

Ayse Ulusoy, Gurdal Sahin, Tomas Björklund, Patrick Aebischer, Deniz Kirik
(2009) Molecular Therapy, 17 p.1574-1584
Journal article

In vivo gene delivery for development of mammalian models for Parkinson's disease

Ayse Ulusoy, Tomas Björklund, Stephan Hermening, Deniz Kirik
(2008) Experimental Neurology, 209 p.89-100
Journal article review

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

Cecilia Lundberg, Tomas Björklund, Thomas Carlsson, Johan Jakobsson, Philippe Hantraye, et al.
(2008) Current Gene Therapy, 8 p.461-473
Journal article

Future Cell- and Gene-Based Therapies for Parkinson's Disease

Tomas Björklund, Asuka Morizane, Deniz Kirik, Patrik Brundin
(2008) Therapeutics of Parkinson's Disease and Other Movement Disorders , p.145-156
Book chapter

Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.

Thomas Carlsson, Tomas Björklund, Deniz Kirik
(2007) Current Gene Therapy, 7 p.109-120
Journal article review

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

Andisheh Eslamboli, Marina Romero-Ramos, Corinna Burger, Tomas Björklund, Nicholas Muzyczka, et al.
(2007) Brain, 130 p.799-815
Journal article

Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

Reza Emdad, David Bonekamp, Hans Peter Sondergaard, Tomas Björklund, Ingrid Agartz, et al.
(2006) Psychotherapy and Psychosomatics, 75 p.122-132
Journal article (letter)

Imaging in cell-based therapy for neurodegenerative diseases.

Deniz Kirik, Nathalie Breysse, Tomas Björklund, Laurent Besret, Philippe Hantraye
(2005) European Journal of Nuclear Medicine and Molecular Imaging, 32 p.417-434
Journal article review